Member 1 Subfamily B ATP Binding Cassette Transporter

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Also Known As:

ATP Binding Cassette Transporter, Subfamily B, Member 1; ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1; CD243 Antigen; PGY-1 Protein; 1, P-Glycoprotein; ABCB1, ATP-Dependent Translocase; ATP Dependent Translocase ABCB1; Antigen, CD243; P Glycoprotein; P Glycoprotein 1; PGY 1 Protein; Protein, MDR1B; Translocase ABCB1, ATP-Dependent; ATP-Dependent Translocase ABCB1; MDR1 Protein; MDR1B Protein; Multidrug Resistance Protein 1; P-Glycoprotein; P-Glycoprotein 1

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
    - Membrane Transport Proteins: 589
      - ATP-Binding Cassette Transporters: 2845
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        ATP-Dependent Organic Anion Transporters
        Subfamily B ATP Binding Cassette Transporter: 258
        Member 1 Subfamily B ATP Binding Cassette Transporter: 6964

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Disease

Drug/Important Bio-Agent (IBA)